Gastrointestinal Disorders

Course Instructor: Pharm Prep

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Module Overview

Sub-Modules

1 Subject

Gastrointestinal

7 Exercises • 140 Learning Materials

Gastro-esophageal Reflux Disease (GERD)

Introduction

Investigations

Alarm Symptoms: Dyspepsia and GERD

GERD: Triggers or Exacerbating Factors

Nonpharmacologic Choices

Pharmacologic Choices

Efficacy - Drugs Used to Treat GERD

Management of GERD

Management of the Refractory Patient

Choices during Pregnancy and Breastfeeding

Algorithms - Management of Patients with Dyspepsia and GERD

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Drug Table - Antacids

Drug Table - H2-receptor Antagonists

Drug Table - Proton Pump Inhibitors

Gastro-esophageal Reflux Disease (GERD)

Exercise

Dyspepsia & Peptic Ulcer Disease (PUD)

Introduction

Investigations

Non-Endoscopic Management of Dyspepsia

Dyspepsia with Normal Endoscopy

Treatment - PUD due to ‘Helicobacter pylori’ Infection

Helicobacter pylori - Eradication Regimens

Prevention of PUD - during ASA or NSAID Therapy

Treatment of PUD during ASA or NSAID Therapy

Choices during Pregnancy and Breastfeeding

Algorithm - Management of Dyspepsia

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Drug Table - Histamine H2-Receptor Antagonists

Drug Table - Mucosal Protective Agents

Drug Table - Neuromodulators

Drug Table - Promotility Agents

Drug Table - Proton Pump Inhibitors

Dyspepsia & Peptic Ulcer Disease (PUD)

Exercise

Inflammatory Bowel Disease (IBD)

Introduction

Investigations

Pharmacologic Choices

Aminosalicylates

Site-Specific Release of 5-ASA Products (examples)

Table: 5-Aminosalicylic Acid (5-ASA) Derivatives

Corticosteroids

Table - Corticosteroids – Systemic and Topical

Biologic Response Modifiers

Table - Biologic Response Modifiers

Immunomodulators

Table - Immunomodulators

Antibiotics / Antidiarrheals / Opiate Analgesics

Immunization

Choices during Pregnancy and Breastfeeding

Ulcerative Colitis

Crohn Disease

Ulcerative Proctosigmoiditis

Algorithm - Management of Crohn Disease

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Algorithm - Management of Ulcerative Colitis

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Algorithm - Management of Ulcerative Proctosigmoiditis

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Inflammatory Bowel Disease (IBD)

Exercise

Irritable Bowel Syndrome

Introduction

Investigations

Rome IV: Diagnostic Criteria / Bristol Stool Form Scale

Bristol stool form scale

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Nonpharmacologic Choices

IBS-Constipation Predominant

IBS-Diarrhea Predominant

IBS-Mixed Pattern

Choices during Pregnancy and Breastfeeding

Algorithm - Irritable Bowel Syndrome

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Drug Table - Antibacterials

Drug Table - Antidiarrheals

Drug Table - Antispasmodics

Drug Table - Bulk-Forming Agents

Drug Table - Guanylate Cyclase-C Agonists

Drug Table - Mixed Mu-Opioid Agonists and Delta Opioid Receptor Antagonists

Drug Table - Serotonin 5-HT4 Receptor Agonists

Drug Table - Selective Serotonin Reuptake Inhibitors

Drug Table - Tricyclic Antidepressants

Irritable Bowel Syndrome

Exercise

Liver Disorders

Introduction

Ascites (Portal Hypertension)

Investigations in Ascites

Therapeutic Choices - Ascites

Table - Drugs Used to Treat Ascites

Algorithm - Management of Ascites Secondary to Portal Hypertension

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Spontaneous Bacterial Peritonitis (SBP)

Therapeutic Choices - SBP

Table - Drugs Used to Treat - SBP

Hepatic Encephalopathy

Table - Drugs Used to Treat Hepatic Encephalopathy

Algorithm - Management of Hepatic Encephalopathy

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Cholestatic Liver Disease

Therapeutic Choices - Cholestatic Liver Disease

Table - Drugs Used to Treat Cholestatic Liver Disease

Algorithm - Management of Cholestatic Symptoms

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Autoimmune Hepatitis

Therapeutic Choices - Autoimmune Hepatitis

Table - Drugs: Autoimmune Chronic Active Hepatitis / Alcohol-Related Hepatitis

Alcohol-Related Liver Disease

Therapeutic Choices - Alcohol-Related Liver Disease

Hereditary Hemochromatosis

Therapeutic Choices - Hereditary Hemochromatosis

Table - Drugs Used to Treat Iron Overload in Hemochromatosis

Wilson Disease

Therapeutic Choices - Wilson Disease

Table - Drugs Used to Treat Wilson Disease

Choices during Pregnancy and Breastfeeding

Liver Disorders

Exercise

Diarrhea

Introduction

Causes of diarrhea

Drugs Associated with Diarrhea

Patient Assessment

Red Flag - Signs and Symptoms

Signs / Symptoms of Dehydration

Prevention

Nonpharmacologic Therapy

Composition - Oral Rehydration Solution Preparations

Recipes - Homemade Oral Rehydration Solution

Diarrhea in Children

Oral Rehydration Solution - Non-breastfed Infants

Table - Nonprescription Drug Therapy for Diarrhea

Additional Pharmacologic Therapies for Diarrhea

Diarrhea in Pregnancy / Elderly

Monitoring of Therapy

Vaccines for Rotavirus Prevention

Algorithm - Management of Patients with Diarrhea

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Diarrhea

Exercise

Constipation

Introduction

ROME IV Diagnostic Criteria for Chronic Functional Constipation

Medications / Conditions Associated with Chronic Constipation

Risk factors - chronic or acute constipation

Patient Assessment

Bristol Stool Form Scale

Image

Red Flag Symptoms Requiring Further Assessment

Prevention

Dietary Fibre in Selected Raw Foods

Nonpharmacologic Therapy

Pharmacologic Therapy

Treatment Considerations

Management - Chronic Constipation

Opioid-Induced Constipation

Constipation in Special Populations

Monitoring of Therapy - Constipation

Algorithm - Assessment and Treatment of Patients with Constipation

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Drug Table - Bulk-Forming Agents

Drug Table - Osmotic Agents

Drug Table - Lubricants

Drug Table - Stimulants

Drug Table - Stool Softeners

Drug Table - Guanylate Cyclase-C Agonists

Drug Table - Serotonin 5-HT4 Receptor Agonists

Drug Table - Enemas

Constipation

Exercise